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Publications

PharmaCog


2010

Babiloni C. et al. Reactivity of cortical alpha rhythms to eye opening in mild cognitive impairment and Alzheimer's disease: an EEG study. http://www.ncbi.nlm.nih.gov/pubmed/20930306

Babiloni C. et al. Stability of clinical condition in mild cognitive impairment is related to cortical sources of alpha rhythms: An electroencephalographic study. http://www.springerlink.com/content/b5672t66721g88j0/ and http://www.ncbi.nlm.nih.gov/pubmed/21181798

Balducci C. APP transgenic mice: their use and limitations. http://www.springerlink.com/content/b5672t66721g88j0/ and http://www.ncbi.nlm.nih.gov/pubmed/21152995

Forloni G. Traslazionale o semplicemente razionale: la ricerca per la malattia di Alzheimer. Ricerca & Pratica 2010 ; n.155 : 183-192.

Frisoni G.B. Alzheimer’s Disease Neuroimaging Initiative in Europe. http://www.ncbi.nlm.nih.gov/pubmed?term=Alzheimer%E2%80%99s%20Disease%20Neuroimaging%20Initiative%20in%20Europe

Frisoni G.B. et al. The clinical use of structural MRI in Alzheimer disease. Nat. Rev. Neurol. 6, 67–77 (2010). http://www.nature.com/nrneurol/journal/v6/n2/abs/nrneurol.2009.215.html

Lorenzi M. et al. Enrichment through biomarkers in clinical trials of Alzheimer's drugs in patients with mild cognitive impairment. Neurobiol Aging. 2010 Aug 31 (8):1443-51. http://www.ncbi.nlm.nih.gov/pubmed?term=Enrichment%20through%20biomarkers%20in%20clinical%20trials%20of%20Alzheimer%27s%20drugs%20in%20patients%20with%20mild%20cognitive%20impairment

Bordet R. et al. Biomarkers for the early stages of clinical development in Alzheimer's disease. Therapie. 2010 Jul-Aug;65(4):285-90, 277-283. doi: 10.2515/therapie/2010040. Epub 2010 Sep 21.


2011

Babiloni C. et al. Cortical sources of resting state electroencephalographic rhythms in Parkinson’s disease related dementia and Alzheimer’s disease. Clinical Neurophysiology. March 2011.

Babiloni C. et al. Resting state cortical electroencephalographic rhythms and white matter vascular lesions in subjects with Alzheimer’s disease: an Italian multicentre study. http://www.ncbi.nlm.nih.gov/pubmed/21673406

Babiloni C. et al., Resting state cortical EEG rhythms are related to gray matter volume in subjects with mild cognitive impairment and Alzheimer’s disease: an ADNI project. Human Brain Mapping

Drago V. et al. Disease Tracking Markers for Alzheimer’s Disease at the Prodromal (MCI) Stage. Journal of Alzheimer's disease. http://www4.unitn.it/Ugcvp/en/Web/Prodotto/2147455440

Languille S. et al. The grey mouse lemur: A non-human primate model for ageing studies. Ageing research Review. http://www.ncbi.nlm.nih.gov/pubmed/21802530

Pifferi F. et al., The sleep-wake cycle in the non-human primate grey mouse lemur (Microcebus murinus): effects of dietary resveratrol supplementation. Chronobiology International


2012

Laurijssens B. et al. Animal Models of Alzheimer’s Disease and Drug Development. Drug Discovery Today. http://dx.doi.org/10.1016/j.ddtec.2012.04.001

Babiloni C. et al. Effects of pharmacological agents, sleep deprivation, hypoxia and transcranial magnetic stimulation on electroencephalographic rhythms in rodents: Towards translational challenge models for drug discovery in Alzheimer’s disease. Clinical Neurophysiology. http://dx.doi.org/10.1016/j.clinph.2012.07.023

Pifferi F. et al. Effects of dietary resveratrol on the sleep‐wake cycle in the non‐human primate gray mouse lemur (Microcebus murinus). Chronobiol Int. 2012 Apr;29(3):261-70


2013

Babiloni C. et al. Effects of acetylcholinesterase inhibitors and memantine on resting state electroencephalographic rhythms in Alzheimer’s disease. May 2013. Clinical Neurophysiology http://dx.doi.org/10.1016/j.clinph.2012.09.017

Deguil J. et al. Evaluation of symptomatic drug effects in Alzheimer’s disease: strategies for prediction of efficacy in humans. September 2013. www.sciencedirect.com/science/article/pii/S1740674913000279

Jovicich J. et al. Brain morphometry reproducibility in multi-center 3T MRI studies: A comparison of cross-sectional and longitudinal segmentations. December 2013. http://dx.doi.org/10.1016/j.neuroimage.2013.05.007

Babiloni C. et al. Effects of pharmacological agents, sleep deprivation, hypoxia and transcranial magnetic stimulation on electroencephalographic rhythms in rodents: towards translational challenge models for drug discovery in Alzheimer's disease. Clin Neurophysiol. 2013 Mar;124(3):437-51. doi: 10.1016/j.clinph.2012.07.023. Epub 2012 Oct 4. Review.

Bonaconsa M. et al. Cell clocks and neuronal networks: neuron ticking and synchronization in aging and aging-related neurodegenerative disease. Curr Alzheimer Res. 2013 Jul;10(6):597-608.

Colavito V. et al. Experimental sleep deprivation as a tool to test memory deficits in rodents. Front Syst Neurosci. 2013 Dec 13;7:106. Review.

Rahman A. et al. Sleep deprivation impairs spatial retrieval but not spatial learning in the non-human primate grey mouse lemur. PLoS One. 2013 May 22;8(5):e64493.

Tarragon E. et al. Octodon degus: a model for the cognitive impairment associated with Alzheimer's disease. CNS Neurosci Ther. 2013 Sep;19(9):643-8. doi: 10.1111/cns.12125. E

Laurijssens B. et al. Animal models of Alzheimer's disease and drug development. Drug Discov Today Technol. 2013 Sep;10(3):e319-27. doi: 10.1016/j.ddtec.2012.04.001. PubMed PMID: 24050129.


2014

Marizzoni M. et al. A new paradigm for testing AD drugs – neuroimaging biomarkers as surrogate outcomes homologous in animals and humans. Drug Discovery Today: Therapeutic Strategies. http://www.sciencedirect.com/science/article/pii/S174067731300017X

Babiloni C. et al. A Review of the Effects of Hypoxia, Sleep Deprivation and Transcranial Magnetic Stimulation on EEG Activity in Humans: Challenges for Drug Discovery for Alzheimer’s Disease. Current Alzheimer Research, 2014, 11http://benthamscience.com/journal/abstracts.php?journalID=car&articleID=120986

Tarragon E. et al. Memantine prevents reference and working memory impairment caused by sleep deprivation in both young and aged Octodon degus. Neuropharmacology 85 (2014) 206-214. http://www.sciencedirect.com/science/article/pii/S0028390814001907

Nombela C. et al. Alpha-Theta Effects Associated with Ageing during the Stroop Test. PLoS ONE 9(5): e95657. doi:10.1371/journal.pone.0095657. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0095657

Jovicich J. et al. Multisite Longitudinal Reliability of Tract-based Spatial Statistics in Diffusion Tensor Imaging of Healthy Elderly Subjects. Neuroimage. 2014 Nov 1;101:390-403. doi: 10.1016/j.neuroimage.2014.06.075. Epub 2014 Jul 12. www.ncbi.nlm.nih.gov/pubmed/25026156


2015

Jovicich J. et al. Longitudinal reproducibility of default-mode network connectivity in healthy elderly participants: A multicentric resting-state fMRI study. NeuroImage. http://www.sciencedirect.com/science/article/pii/S1053811915007661

Waldron A.-M. et al. Quantitative μPET Imaging of Cerebral Glucose Metabolism and Amyloidosis in the TASTPM Double Transgenic Mouse Model of Alzheimer'd disease. Current Alzheimer Research, 2015, 12. http://benthamscience.com/journal/abstracts.php?journalID=car&articleID=132977

Balducci C. et al. The Continuing Failure of Bexarotene in Alzheimer's Disease Mice. J Alzheimers Dis. 2015 Mar 16. http://www.ncbi.nlm.nih.gov/pubmed/25777514/

Infarinato F. et al. On-Going Frontal Alpha Rhythms Are Dominant in Passive State and Desynchronize in Active State in Adult Gray Mouse Lemurs. PLoS One. 2015; 10(11): e0143719. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664384/

Babiloni C. et al. Spectral ongoing eeg markers of motor activity in mouse models in physiological aging and Alzheimer's disease. Alzheimer's & Dementia. http://www.alzheimersanddementia.com/article/S1552-5260(15)00594-4/abstract/

Micotti E. et al. Striatum and entorhinal cortex atrophy in AD mouse models: MRI comprehensive analysis. http://www.ncbi.nlm.nih.gov/pubmed/25433456


2016

Martin-Trias P. et al. Translational challenge models in support of efficacy studies: Neurobehavioral and cognitive changes induced by Transcranial Magnetic Stimulation in healthy volunteers. CNS & Neurological Disorders - Drug Targets, Volume 15. http://benthamscience.com/journals/cns-and-neurological-disorders-drug-targets/article/142301/

Galluzzi S. et al. Clinical and biomarker profiling of prodromal Alzheimer's disease in workpackage 5 of the Innovative Medicines Initiative PharmaCog project: a 'European ADNI study'. http://www.ncbi.nlm.nih.gov/pubmed/26940242/

Jovivich J. et al. Test-retest reliability of the default mode network in a multi-centric fMRI study of healthy elderly: Effects of data-driven physiological noise correction techniques. http://www.ncbi.nlm.nih.gov/pubmed/26990928/

Deleye S. et al. The Effects of Physiological and Methodological Determinants on 18F-FDG Mouse Brain Imaging Exemplified in a Double Transgenic Alzheimer Model. http://mix.sagepub.com/content/15/1536012115624919.abstract/

Jovivich J. et al. Longitudinal reproducibility of default-mode network connectivity in healthy elderly participants: A multicentric resting-state fMRI study. http://www.ncbi.nlm.nih.gov/pubmed/26163799

Marizzoni M. et al. Longitudinal reproducibility of automatically segmented hippocampal subfields: a multisite European 3T study on healthy elderly. http://www.pubfacts.com/detail/26043939/Longitudinal-reproducibility-of-automatically-segmented-hippocampal-subfields-A-multisite-European-3

Albi A. et al. Free water elimination using a bi-tensor model improves test-retest reproducibility of diffusion tensor imaging indices in the brain: a longitudinal multisite study of healthy elderly subjects. https://www.ncbi.nlm.nih.gov/pubmed/27519630

Del Percio C. et el. Ongoing electroencephalographic rhythms related to cortical arousal in wild type mice: the effect of aging. http://www.neurobiologyofaging.org/article/S0197-4580(16)30217-2/fulltext?rss=yes

 

 
 

Last Updated: Monday 18 January 2016

 

 
  • Acknowledgements

    The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007-2013) for the Innovative Medicine Initiative under Grant Agreement No 115009.
  • Innovative Medicines Initiative
  • European Union
  • European Federation of Pharmaceutical Industries and Associations
 
 

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